Formulated Nasal Moisturizing Spray and
Sinus Irrigation Solution
Is Breathe·Ease ?
is a new moisturizing and irrigation solution for the
nose that is both effective and economical. Breathe-ease
unique "Ringers-Locke" solution is formulated
to approximate the body's natural salinity and electrolyte
composition. This unique formulation is reported in
medical journals best for nasal cilia to prevent the
nasal cilia from slowing due to infection, allergy,
and contagion and more appropriate than regular saline.
solution incorporates a formula proven effective in
clinical trials. Breathe·Ease is additive-free,
and is as economical as possible: You make Breathe·Ease
solution yourself by just mixing our formula with water
in our refillable spray bottle included with every package.
g of powder for nasal solution.
teaspoon measuring spoon - white - for adding to
4 ounces of boiled or bottled water for spray.
teaspoon measuring spoon - blue to add to a pint
of water for irrigation with the Grossan Pulsatile
is Breathe·Ease used for?
nose drops are needed for most nasal and sinus conditions.
They are recommended for dryness, crusting, and as an aid
to normal nasal function. Saline sprays can also be used
to prevent and treat nose bleeds.
nose is supposed to moisten inhaled air, helping to maintain
a moist environment for the cilia in the sinuses. These
cilia are the body's first line of defense against infection.
The moist, mucous environment also forms a pathway for the
good white cells to reach the bad bacteria that may attempt
to infect the body through inhalation.
dryness, itching, or crusting in the nose means that a moisturizer
is needed for the nose to do it's job. Saline had
always been considered the most common, safe, and
simple such moisturizer. Today we know that the preservatives
that must be added to insure a long long shelf life can
be harmful or irritating to the nose, especially when the
nose is irritated already . Here is a partial list
of the additives found in saline nasal sprays:
So it is important to avoid any of these preservatives that
might irritate an already sore nose. So Breathe·Ease
was developed as a means of providing a solution for the
dry irritated nose.
the purpose of a saline type spray is to restore normal
cilia function. Professor Wilbert M Boek of University
Hospital, Utrecht reported that certain solutions containing
potassium chloride, calcium chloride, sodium bicarbonate,
and salt were much better for restoring nasal/sinus cilia
than those without these ingredients. Clinical experience
has borne this out. Hence Breathe·Ease is a formula
based on Professor Boek's findings. He showed that
a product called Locke-Ringer's solution, used in the hospital
for intravenous administration to patients needing fluids
did a better job of restoring cilia function than physiologic
saline. Plus he cautioned against the use of some of the
preservatives that can harm the delicate nasal membranes.
is especially designed for use by the child. The incidence
of children with sinusitis is increasing at an alarming
rate. Many of these children could be helped by regular
use of moisturizer solution. Breathe·Ease is for kids:
preservative to burn
bottle that kids can handle easily
surface to place the kid's favorite sticker on. "See,
Pokeman uses this spray too"
use with the Grossan Sinus Irrigator
Experience has shown that when the Breathe·Ease
formula is used for Grossan Sinus irrigation, patients get
better clearing of sinus infection and post nasal drip.
This is because there is no iodine, preservatives, or silica
in the formula. The measuring spoon allows for accurate
measure. Add one teaspoon of Breathe·Ease to a pint
of water in the Water Pik basin. Stir, then use as directed
to restore cilia and remove purulent material.
the white 1/4 teaspoon measuring spoon, add 1/4 ounce Breathe·Ease
formula powder to four ounces of boiled or bottled water.
Spray nose as needed. Change once a week. The spray bottle
can be used as a spray, to irrigate directly, or just as
kids or adults with colored discharge: 3 to 4x a day.
kids or adults with nose bleed 3 to 4 x a day.
dry weather twice a day.
smog days twice or 3x a day.
prevent nose bleeds twice a day.
of spray bottle to irrigate:
During the pollen season can use the spray bottle as an
irrigator to remove pollen from the nose. Try this 3x
a day after downtown smog or diesel exposure, irrigate
to remove the particular matter.
four dollars or more plus tax for a penny's worth of saline
solution must discourage a lot of people. With Breathe·Ease
you get 150 or more refills of solution, refilling once
a week. You use the 1/4 teaspoon added to four ounces
of boiled or bottled water. You can even save the surplus
for further use. So its economic to use for irrigation
with the spray bottle as well.
worry about mixing the right amounts of saline. One teaspoon
can vary enormously, as much as 40 % in one study. Here
the teaspoon is exactly measured so there is no mistake.
use with the Grossan Sinus Irrigator you get over 60 day's
supply. With this special formula, and because there
are no preservatives, silica, or iodine, many patients require
less days of irrigation.
doctor tells you to irrigate with warm saline. Warm solution
helps bring more circulation to the area, and besides, it
feels good. Yet, some solutions with additives can only
be used at room temperature.
many customers once they have opened the store bought saline
solution and carried it about for weeks, they no longer
consider it to be fresh and toss it to buy a fresh bottle.
Part of this has to do with the preservatives giving a "smell"
kind of sensation. With Breathe·Ease you know its
fresh because you make it every week.
preservative Benzalkonium Sodium causes problems with nasal
sprays. Around 1985, it was noted that the number and severity
of cases of rhinitis medicamentosum was increasing with
increased use of benzalkonium, an antibacterial preservative
found in most over-the- counter prepared saline nasal spray
products. Rhinitis medicamentosum means that the nose gets
stuffy and congested after use of nose drops such as oxymetazoline
(Afrin®). The more the nose drops are used, the more "rebound"
when the drug wears off, that is, the worse the patient
gets after the drops wear off, requiring more and more use
of the drops. The drops become effectively addictive, and
worse, the nose is always stuffy anytime the drug is not
active in the nose.
it was discovered that you could get rhinitis medicamentosum
just form the Benzalkonium alone, as well as saline with
Benzalkonium. So, it wasn't the nasal medication oxymetazoline
that was responsible, but the Benzalkonium. The oxymetazoline
did shrink the nose nicely, but the benzalkonim caused a
additive problems are so important that the Dannemiller
Memorial Educational Foundation gives special training to
doctors on this subject. This training emphasizes that if
you are allergic or have an infection, the additives can
be more irritating than when you are "normal".
articles on the negative effects of Benzalkonium include:
Mucosa exposed to benzalkonium chloride showed squamus cell
metaplasia ( the normal cells changed to undesirable cells).
Benzalkonium chloride appears to be potentially toxic to
benzalkonium chloride has toxic effects on human respiratory
mucosa and human neutrophils. It destroyed mucosa and inhibited
human neutrophil action.Benzalkonium chloride induces mucosal
swelling, which explains why the presence of this preservative
in a decongestant spray aggravates rhinitis medicamentosa.
and hypertonic saline solutions impair ciliary activity
in vitro. Boek WM. Laryngoscope, 109(3):396-9 1999 Mar Physiological
salt solution (0.9%) was found to slow cilia movement. Locke-Ringers
solution with soda bicarbonate, potassium and calcium chloride,
and salt was found best for cilia. "This solution is
more appropriate than saline for nasal irrigator and nebulazation
or sinus lavage." He reported complete ciliastasis
with some hypertonic solutions, often within 5 minutes of
chloride in a decongestant nasal spray aggravates rhinitis
medicamentosa in healthy volunteers. Clin Exp Allergy.1995;
25:957-965 Benzalkonium chloride induces mucosal swelling,
which explains why the presence of this preservative in
a decongestant spray aggravates nasal/sinus symptoms
of topical nasal steroids on human respiratory mucosa and
human granulocytes in vitro. Steinsv¡ag S. Acta Otolaryngol
(Stockh), 116(6):868-75 1996 "It is concluded that
benzalkonium chloride has toxic effects on human respiratory
mucosa and human neutrophils in vitro."
of topical corticosteroids and topical antihistaminics on
ciliary epithelium of human nasal mucosa in vitro. Hofmann
T. HNO, 46(2):146-51 1998 Feb "An irreversible cessation
of ciliary movement was observed in all cells exposed to
nasal sprays containing benzalconium chloride....."
"we recommend that this preservative should not be
used anymore in topical nasal medications."
effects of topical nasal steroids on rat respiratory mucosa
in vivo, with special reference to benzalkonium chloride.
Berg OH. Allergy, 52(6):627-32 1997 Jun "In conclusion,
benzalkonium chloride appears to be potentially toxic to
the nasal mucosa."
clinical trial of hypertonic saline nasal spray in subjects
with the common cold or rhinosinusitis. Adam P. Arch Fam
Med, 7(1):39-43 1998 Jan-Feb Hypertonic saline does not
improve nasal symptoms or illness duration in patients with
the common cold or rhinosinusitis. Thirty two percent of
users noted burning and wouldn't use the product again.